NIG International Symposium 2015 JapanQ-Bioweek

From Japanese society for quantitative biology

Latest information

go to Japanese page

  • Home page of the Japan Q-Bio week – force, information, and dynamics opens(07152015).
  • Downloading the program and poster abstracts will be available. Details will be open to participants by e-mail(tba).
  • admission free.
  • The submission of abstracts will start for poster presentations on the beginning of September. Details will be sent to participants by e-mail. Deadline is planning during the first week of November(tba).

Registration

The registration will be open soon.

Important Notices

The official language of the meeting is English.

Due to the capacity of the venue, the numbers of participants are limited to approximately 150. It is highly recommended to register as soon as possible after the registration begins. In recent years, the registrations closed in a few days.

Outline of the "Japan Q-Bio week – force, information, and dynamics"

Objective

The symposium aims to bring together biologists using various quantitative approaches to reveal new concepts in cell and developmental biology. We have settled three main topics for our symposium, as you may find in the title of the symposium - force, information, and dynamics. Modern biology has progress mainly through characterizing gene functions. Now, we believe complementary studies on forces, information, and dynamics are critical to reveal new concepts in biology. Quantitative analysis is a common approach for these emerging fields of biology, and planned to gather researchers to discuss and share their views and approaches.

Workshops and two Main Symposium

In the Japan Q-Bio week, we provide several workshops before the main symposiums during Jan 7th to 8th, 2016, at the Institute of Industrial Science, the University of Tokyo.

On the Symposium at the Institute of Industrial Science, the University of Tokyo, we organize oral sessions about three featured quantities and the beyond, titled: "Quantity - FORCE -", "Quantity - SYMMETRY -", "Quantity - INFORMATION -", and "Quantities and beyond". We will also have poster sessions with a coffee break, the lunch time on 2nd day, and with supper on the evening. In the poster sessions, all general participants may give poster presentations.

On the second Main Symposium at the National Institute of Genetics on Jan 13th and 14th 2016, we will have more interactive sessions with the fascinating researchers in the National Institute of Genetics.

All these workshops and Symposiums are mainly supported by the National Institute of Genetics. Institute of Industrial Science, the University of Tokyo also supports our activity. We also thank to Dainippon Sumitomo Pharmacy for their support.

Date

  • Workshops : Jan 7th and 8th, 2016.
  • 1st Symposium (at Institute of Industrial Science, the University of Tokyo): Jan 9th - 12th, 2016.
  • 2nd Symposium (at National Institute of Genetics): Jan 13th - 14th, 2016.

Venue for workshops and the 1st Main Symposium

Convention hall, An Block, Institute of Industrial Science,
Komaba Ⅱ Research Campus, The University of Tokyo.
Access to Komaba Ⅱ Research Campus
Campus map

Venue for the 2nd Main Symposium

D. Lecture Hall, National Institute of Genetics, Mishima
Access to National Institute of Genetics
D. Lecture Hall

Registration Fee

  • workshops and symposiums : free
  • Alcoholic beverages in the banquet ( if you wish ) : tba

Seating capacity

  • Approximately 150, excluding speakers ( approx. 20 people ).

Remarks

  • Poster sessions
    • The size of a poster panel is 1130 mm width and 1630 mm height. Up to a standard B0 size will be possible to post.
  • Internet
    • Wireless internet access will be available. Limited numbers of electric outlets and wired LAN cables are also available.

Scientific Program

satellite workshops ( Jan. 7th )

All workshops are admission free. Please register from the registration page[tba].

Workshop 1


Time: 13:00 - 17:00

Theories in Quantitative Biology(??)
by Akira Funahashi( Dept. of Biosciences and Informatics, Keio University )

References:
1. UNIXワークステーションによる科学技術計算ハンドブック: 基礎篇C言語版, 戸川隼人 (サイエンス社, 1998) [1]

2. 数値計算の常識, 伊理正夫, 藤野和建 (共立出版, 1985) [2]

Tutorial 2


Time: 13:00 - 14:30
Chair: TBA

What are researchers on image informatics doing?
by Seiichi Uchida( Kyushu University )

References:
A publication list of the speaker is available [3]
A homepage of bioimageinformatics is also available.[4]

Tutorial 3


Time: 15:00 - 16:30
Chair: TBA

Introduction to Bayesian analysis: concept and usage
by Kazuyuki Nakamura( Grad. Sch. of Advanced Mathematical Sciences, Meiji University )

References:
K. Nakamura, R. Yoshida, M. Nagasaki, S. Miyano and T. Higuchi, "Parameter estimation of in silico biological pathways with particle filtering towards a petascale computing," The Proceedings of 14th Pacific Symposium on Biocomputing, pp. 227-238, 2009.

H. Koyama, T. Umeda, K Nakamura, T. Higuchi and A. Kimura, “A high-resolution shape fitting and simulation demonstrated equatorial cell surface softening during cytokinesis and its promotive role in cytokinesis,” PLoS ONE 7(2), e31607, 2012.

樋口知之編著「データ同化入門―次世代のシミュレーション技術―」

Tutorial 4


Time: 17:00 - 18:00

Crosslinking Q-bio and Omics
by Itoshi Nikaido( RIKEN CDB )

References:
ENCODE Project Consortium, An integrated encyclopedia of DNA elements in the human genome, Nature. 2012 Sep 6;489(7414):57-74.[5].

Sessions ( Nov. 24th, 25th )

Session: Life and constructive approaches



Date and Time: Nov. 24th 10:30-12:30
Chair: TBA
Speakers:
Hirohide Saito (Kyoto University, The Hakubi Center, CiRA )
Yutaka Sumino ( Aichi Univ. of Edu. )
Mitsuhiro Matsuda ( Dept. of Cell and Dev. Biol., Grad. Sch. of Biostudies, Kyoto Univ. )
Yusuke T. Maeda ( The Hakubi Center, Kyoto University; PRESTO )


Synthetic RNA-based approaches towards autonomous control of mammalian cell fate
by Hirohide Saito (Kyoto University, The Hakubi Center, CiRA )

References:
1.Saito H, Kobayashi T, Hara T, Fujita Y, Hayashi K, Furushima R, Inoue T., Synthetic translational regulation by an L7Ae-kink-turn RNP switch., Nat Chem Biol. 2010 Jan;6(1):71-8.[6]
2.Ohno H, Kobayashi T, Kabata R, Endo K, Iwasa T, Yoshimura SH, Takeyasu K, Inoue T, Saito H., Synthetic RNA-protein complex shaped like an equilateral triangle., Nat Nanotechnol. 2011 Feb;6(2):116-20.[7]
3.Saito H, Fujita Y, Kashida S, Hayashi K, Inoue T., Synthetic human cell fate regulation by protein-driven RNA switches., Nat Commun. 2011 Jan 18;2:160.[8]
4.Kashida S, Inoue T, Saito H., Three-dimensionally designed protein-responsive RNA devices for cell signaling regulation., Nucleic Acids Res. 2012 Jul 18.[9]

Large scale vortex formation of self-propelled microtubules
by Yutaka Sumino ( Aichi Univ. of Edu. )

References:
[1] S. Ramaswamy, "The mechanics and statistics of active matter," Ann. Rev. Cond. Matt. Phys. 1, 323-345 (2010).
[2] Y. Sumino, K. H. Nagai, Y. Shtaka, D. Tanaka, K. Yoshiakwa, H. Chaté, and K. Oiwa, ."Large-scale vortex lattice emerging from collectively moving microtubules, " Nature 483, 448-452 (2012). [10]
[3] T. Vicsek, A. Czirók, E. Ben-Jacob, I. Cohen, and O. Schochet, "Novel type of phase transition in a system of self-driven particles," Phys. Rev. Lett. 75, 1226-1229 (1995). [11]
[4] G. Grégoire and H. Chaté "Onset of Collective and Cohesive Motion" Phys. Rev. Lett. 92, 025702 (2004). [12]


Multicellular patterns generated by intercellular feedback circuits
by Mitsuhiro Matsuda ( Dept. of Cell and Dev. Biol., Grad. Sch. of Biostudies, Kyoto Univ. )

References:
Matsuda M, Koga M, Nishida E, Ebisuya M. Synthetic signal propagation through direct cell-cell interaction. [13]

DNA and RNA in temperature gradients: Molecular transport from the origin of life to cell manipulation
by Yusuke T. Maeda ( The Hakubi Center for Advanced Research, Kyoto University; PRESTO, Japan Science and Technology Agency )

References:
[1] YT Maeda, A Buguin, A Libchaber (2011) Phys. Rev. Lett. 107: 038301.
[2] YT Maeda, T Tlusty, A Libchaber, PNAS in press.

Session: Life dynamics through statistical time-series analysis



Date and Time: Nov. 24th 15:45-17:15
Chair: TBA
Speakers:
Michio Hiroshima ( RIKEN QBiC/ASI )
Toshiaki Omori ( Graduate School of Engineering, Kobe University )
Yohei Kondo ( Department of Basic Science, The University of Tokyo )


Single-molecule analysis of ErbB signaling in living cells
by Michio Hiroshima ( RIKEN QBiC/ASI )

References:
[1] Low-Nam S., Lidke K., Cutler P., Roovers R., van Bergen en Henegouwen P., Wilson B., Lidke D. ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding. Nature Str. Mol. Biol. 2011;18(11):1244-1250.
[2] Hiroshima M., Saeki Y., Okada-Hatakeyama M., Sako Y. Dynamically varying interactions between heregulin and ErbB proteins detected by single-molecule analysis in living cells. Proc. Natl. Acad. Sci. USA. 2012;109(35):13984-13989.


Estimating Spatiotemporal Dynamics of Dendritic Membrane Potential
– Information Extraction Using Bayesian Statistics -

by Toshiaki Omori ( Graduate School of Engineering, Kobe University )

References:
[1]N. Spruston. Pyramidal Neurons: Dendritic Structure and Synaptic Integration Nature Rev. Neurosci. (2008) 9, 206.
[2] T. Omori, T. Aonishi, H. Miyakawa, M. Inoue, and M. Okada. Estimated Distribution of Specific Membrane Resistance in Hippocampal CA1 Pyramidal NeuronBrain Res. (2006) 1125, 199
[3] T. Omori, T. Aonishi, H. Miyakawa, M. Inoue, and M. Okada. Steep Decrease in the Specific Membrane Resistance in the Apical Dendrites of Hippocampal CA1 Pyramidal NeuronsNeurosci. Res. (2009) 64, 83


Reconstructing core mechanisms from single-cell time series
by Yohei Kondo ( Department of Basic Science, The University of Tokyo )>

References:
Y. Kondo, K. Kaneko, S. Ishihara, Identifying dynamical systems with bifurcations from noisy partial observation [14]

Session: New fields in quantitative biology



Date and Time: Nov. 25th 10:00-11:30
Chair: TBA
Speakers:
Yutaro Kumagai ( IFReC, Osaka University )
Masaya Oki ( Department of Applied Chemistry & Biotechnology, Graduate school of engineering, University of Fukui )
Yoshimi Haga ( Glycometabolome Team, RIKEN Advanced Science Institute )


Control of innate immune response via RNA degradation
by Yutaro Kumagai ( IFReC, Osaka University )

References:
[1] Takeuchi O and Akira S. "Pattern recognition receptors and inflammation" Cell. 2010 Mar 19;140(6):805-20.
[2] Hornung G and Barkai N. "Noise propagation and signaling sensitivity in biological networks: a role for positive feedback" PLoS Comput Biol. 2008 Jan;4(1):e8.


Analysis of the epigenetic gene expression mechanism by using the single cell chase system
by Masaya Oki ( Department of Applied Chemistry & Biotechnology, Graduate school of engineering, University of Fukui )

References:
1.Hatanaka A, Chen B, Sun JQ, Mano Y, Funakoshi M, Kobayashi H, Ju Y, Mizutani T, Shinmyozu K, Nakayama J, Miyamoto K, Uchida H, Oki M., Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex., Genes Genet Syst. 2011;86(5):305-14.[15]
2.Sun JQ, Hatanaka A, Oki M., Boundaries of transcriptionally silent chromatin in Saccharomyces cerevisiae., Genes Genet Syst. 2011;86(2):73-81.[16]
3.Dhillon N, Oki M, Szyjka SJ, Aparicio OM, Kamakaka RT., H2A.Z functions to regulate progression through the cell cycle., Mol Cell Biol. 2006 Jan;26(2):489-501.[17]
4.Oki M, Kamakaka RT., Barrier function at HMR., Mol Cell. 2005 Sep 2;19(5):707-16.[18]
5.Oki M, Valenzuela L, Chiba T, Ito T, Kamakaka RT., Barrier proteins remodel and modify chromatin to restrict silenced domains., Mol Cell Biol. 2004 Mar;24(5):1956-67.[19]
6.Oki M, Kamakaka RT., Blockers and barriers to transcription: competing activities?, Curr Opin Cell Biol. 2002 Jun;14(3):299-304.[20]


Imaging of glycoforms: a sweet tool to visualize the dynamics of specific glycoproteins
by Yoshimi Haga ( Glycometabolome Team, RIKEN Advanced Science Institute )

References:
1.Haga Y, Ishii K, Hibino K, Sako Y, Ito Y, Taniguchi N, Suzuki T., Visualizing specific protein glycoforms by transmembrane fluorescence resonance energy transfer., Nat Commun. 2012 Jun 19;3:907.[21]
2. Haga Y, Ishii K, Suzuki T., N-glycosylation is critical for the stability and intracellular trafficking of glucose transporter GLUT4., J Biol Chem. 2011, 286(36):31320-7. [22]

Session: Robustness in life



Date and Time: Nov. 25th 14:00-16:00
Chair: TBA
Speakers:
Hidehiko Inomata ( RIKEN CDB )
Daisuke Kiga ( Dept. of Computational Intelligence and Systems Science, Tokyo Institute of Technology )
Tetsuhiro S. Hatakeyama ( Department of Basic Science, The University of Tokyo )
Tomoya Kitajima ( RIKEN CDB )


Embryo Size-dependent Self-regulation of Spemann's Organizer Signal by Dynamic Degradation Control
by Hidehiko Inomata ( RIKEN CDB )

References:
Inomata H, Haraguchi T, Sasai Y., Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation., Cell. 2008 Sep 5;134(5):854-65. [23]

PDCA cycle of artificial genetic circuit based on modeling and quantitative results
by Daisuke Kiga ( Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology )

References:
Sekine R, Yamamura M, Ayukawa S, Ishimatsu K, Akama S, Takinoue M, Hagiya M, Kiga D. Tunable synthetic phenotypic diversification on Waddington's landscape through autonomous signaling., Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17969-73.

Temperature compensation of biochemical oscillators by “enzyme-limited competition”
by Tetsuhiro S. Hatakeyama ( Department of Basic Science, The University of Tokyo )

References:
Hatakeyama TS, Kaneko K., Generic temperature compensation of biological clocks by autonomous regulation of catalyst concentration., Proc Natl Acad Sci U S A. 2012 May 22;109(21):8109-14. [24]

Quantitative live imaging of chromosome dynamics in mammalian oocytes
by Tomoya Kitajima ( RIKEN CDB )

References:
Kitajima TS, Ohsugi M, Ellenberg J., Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes., Cell. 2011 Aug 19;146(4):568-81. [25]

Poster sessions ( Nov. 24th, 25th )

  • Session 1 (11/24 13:30-15:30)
    • 13:30-14:30 Presentations for posters of odd number
    • 14:30-15:30 Presentations for posters of even number
  • Session 2 (11/24 18:00-20:00)
    • 18:00-20:00 Free
  • Session 3 (11/25 11:45-14:00; including lunch time)
    • 12:00-12:30 Presentations for posters of odd number
    • 12:30-13:00 Presentations for posters of even number
    • 13:00-14:00 Free
  • Poster presentations
  • Remarks
    • The poster room will be available to present your poster from Nov. 24th. Please remove your poster by Nov. 25th 14:00.

Other events ( Nov. 24th )

  • Poster guide( instructions of poster presentations )
  • Banquet